Postgenomic Technologies for Precision Medicine (MA030472)

(10/27/2021-12/21/2021)

Course Memo

This course offers lectures, seminars, and practical classes on implementation of post-genomics multi-omics technologies for medicine. The course is a continuation of the “Biomedical Mass-spectrometry” and “Omics Technologies” courses. The course covers on-going Omics lab research studies in the field of infectious and somatic diseases (including COVID-19 and its health consequences), neurodegenerative diseases (Alzheimer's disease) and various cancers. After an introduction to mass spectrometry (MS), the course will demonstrate how MS-based modern multi-Omics techniques (including those that are being developed at Skoltech) are being used to solve vital medical problems. Relevant clinical studies and cases will be discussed, including the multiplexed determination of the relative and absolute concentrations of different Omics markers in plasma, tissues, and other patient biofluids, the use of big data analysis to search for disease-specific molecular signatures for diagnostics/prognostics and for developing diagnostics kits. In addition, the visualization of Omics biomarkers on tissue sections by MALDI-MS will be demonstrated by our on-going studies (e.g., on brain tumor). MS-based proteomic and phosphoproteomic analyses of signaling pathways for the dissection tumor pathogenesis will also be demonstrated. A significant part of the course will be devoted to the implementation of bioinformatics and big data analysis tools, including machine learning and artificial intelligence (AI) for clinical multi-omics studies, with demonstrations to show how it helps to improve therapeutic outcomes. By successfully completing this course, students will have acquired a deeper knowledge of how multi-Omics assays are used in medical research, the principals of bioinformatics and big data analysis for discovering prognostic and diagnostic biomarkers, and the generation of specific assays and kits to improve precision medicine.